Only 180 riders started Stage 2 of the 2021 Tour de France, after Marc Soler of Movistar Team was unable to continue in the race. All 180 came safely home after two ascents of Mur-de-Bretagne, a steep but relatively short climb that Mathieu van der Poel owned.

With an even number of riders, there was no Point d’Appui awarded for Stage 2. Julien Simon of TotalEnergies in 90th place and Connor Swift (GBr) Team Arkea-Samsic shared les cuspides on the stage. Simon shared les Cuspides on Stage 3 of the 2018 Tour de France as well.

Tony Martin of Jumbo-Visma and Amund Grøndahl Jansen of Team BikeExchange shared the Lanterne Rouge with a time of 29 minutes and 46 seconds behind the leader, van der Poel, who due to time bonuses was able leap past Julian Alaphilippe and pull on the yellow jersey.